5 Essential Elements For cees dekker
5 Essential Elements For cees dekker
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Our team reports bacterial cell division and is aiming to constitute a ‘base up biology’ in synthetic cells that may autonomously divide. Our main desire lies in cell division, chromatin structure, and spatial control.
Dynamics of initiation, termination and reinitiation of DNA translocation through the motor protein EcoR124I
I'm able to hardly imagine how I, as a geneticist, would be able to master essential physics, not to mention compete at the top. How did you go about it?
This yielded a breakthrough. Inside only some months, we had been able to measure transportation by way of an individual solitary-walled carbon nanotube. Based on very low-temperature experiments by a brilliant PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies by having an active investigation lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes have been legitimate quantum wires with really extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Our investigate ranges within the biophysics of DNA to artificial cells and further than. Be sure to take a look underneath for the spectrum of our latest initiatives.
All parameters have been the exact same for every panel in this video, except for the Preliminary placement in the 6hb rod (revealed in blue) on the nanopore. Simulations that terminated early because of translocation in the rod throughout the pore are marked by a grey qualifications.
Nanopores signify an elegant and versatile tool to evaluate one molecules. We investigate novel detection modes with solid-state nanopores as well as various ways to evaluate proteins with nanopores. Jobs encompass the subsequent:
Knowing basic procedures regulating the spatial and dynamic organisation with the DNA in Are living cells.
Presently, we also recognized that it ought to be achievable to work with an individual semiconducting carbon nanotube to produce a transistor — and we set out to really make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and utilised the underlying silicon substrate as being a gate electrode, establishing The essential 3-terminal format of a field-effect transistor (Fig.
An built-in microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
2001, discovery of solitary-electron transistors at place temperature based upon nanotubes; realization of to start with logic circuits with carbon nanotube devices; and discovery of the molecular structure of DNA repair enzymes with AFM
2008, very first observation cees dekker of protein-coated DNA translocation by means of nanopores; resolved the origin of the electrophoretic force on DNA in nanopores; discovered an important velocity maximize of microtubules in electric powered fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid
It was an exceptionally interesting time, for the duration of which I been given lots of assist from Delft College of Know-how, the place I was a professor at enough time, And that i started many collaborations with molecular biologists. That served me discover a good deal.’